Aminoglutethimide Dosage
Applies to the following strengths: 250 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Cushing's Syndrome
250 mg orally every 6 hours. Adrenocortical response should be monitored carefully, preferably in a hospital setting, while initiating therapy. If cortical suppression is inadequate, the dose may be titrated in 250 mg increments every 1 to 2 weeks to a maximum daily dose of 2 g.
Usual Adult Dose for Breast Cancer
250 mg orally twice a day. The dose may be increased after 2 weeks to 250 mg orally 4 times a day based on clinical response and patient tolerance of the drug. The typical dosage range is 250 to 1000 mg/day. Aminoglutethimide is usually used concomitantly with either hydrocortisone or cortisone acetate in this clinical setting to prevent ACTH reflex phenomenon.
Usual Adult Dose for Prostate Cancer
250 mg orally twice a day. The dose may be increased after 2 weeks to 250 mg orally 4 times a day based on clinical response and patient tolerance of the drug. The typical dosage range is 250 to 1000 mg/day. Aminoglutethimide is usually used concomitantly with either hydrocortisone or cortisone acetate in this clinical setting to prevent ACTH reflex phenomenon.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Precautions
Patients with renal or liver dysfunction should be carefully monitored for aminoglutethimide toxicity. Dosing should be conservative.
Dialysis
Data not available
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- Drug class: adrenal corticosteroid inhibitors
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